Zac Sabbath, the writer of Playing D&D With Porn Stars blog has most awesome rpg idea and setting ever.
Go take a look:
This is just so awesome, it's beyond description. Humongous infinite scifi-dungeon where anything is possible. This is like cyberpunk mixed with basic D&D dungeoncrawl with hardcore scifi to low fantasy.
So, go and take a look at this monstrosity of roleplaying game design. It is brilliant!